Dynamic pathway regulation balances flux between growth of cells and production of desired metabolites. Once sufficient biomass and cellular resources have accumulated from an initial growth phase, substrate flux can then be diverted into the production pathway.
Oct 20, 2017
Systems for autonomous induction of pathway regulation are increasingly being developed, which include metabolite responsive promoters, biosensors, and quorum ...
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Feb 13, 2017 · Dynamic regulation of pathway fluxes has emerged as a new frontier in metabolic engineering. The QS system we have developed enables precise ...
Dynamic pathway regulation is designed to be on a par with the native metabolism, that is, to sense changes in the environment and/or metabolic state and ...
Mar 5, 2018 · Dynamic regulation is a metabolic engineering strategy for improving production in pathways with toxic intermediates, essential competing ...
Nov 1, 2013 · New techniques have been developed to tailor expression strength by means of promoter libraries, mRNA stability or ribosome binding strength.
Sep 11, 2020 · Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4 ...
Jul 2, 2021 · Dynamic pathways regulate the carbon flow between balancing cell growth and the production of metabolites. Dynamic regulation can be divided ...
To overcome these limitations, dynamic pathway regulation has emerged as a strategy to balance flux between growth and production, such that titers and yields ...
Metabolic engineers have used dynamic regulation to redirect endogenous flux toward product formation, balance the production and consumption rates of key ...