Dynamic regulation is a metabolic engineering strategy for improving production in pathways with toxic intermediates, essential competing reactions, or flux imbalances.
Mar 5, 2018
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Dynamic pathway regulation has proved successful in improving production of molecules by balancing flux between growth of cells and production of metabolites.
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Abstract. Microbial cell factories are a renewable source for the production of biofuels and valuable chemicals. Dynamic pathway regulation has proved ...
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Systems for autonomous induction of pathway regulation are increasingly being developed, which include metabolite responsive promoters, biosensors, and quorum ...
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Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels. It has been widely applied ...
Nov 2, 2020 · Compared to static regulation, dynamic control is prevalent in organisms by nature and helps cells to adapt organismal metabolic states to ...
To improve product titer, yield, and selectivity, the pathways engineered into microbes must be optimized. One strategy for optimization is dynamic pathway ...
In autonomous dynamic regulation, specific gene activation and repression can be initiated by the cells without manual control. With cell growth, the carbon ...
Jun 22, 2020 · • A closed-loop regulated flavonoid production pathway shows robust dynamic response.
We apply this approach to regulate farnesyl pyrophosphate (FPP) production in the isoprenoid biosynthetic pathway in Escherichia coli. This strategy improved ...