- Meloxicam and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs) that work by blocking enzymes that produce inflammation and pain12. The main difference between them is that ibuprofen blocks COX-1, the enzyme that protects your stomach from irritation, while meloxicam mostly blocks COX-2, especially at lower doses1. This means that ibuprofen is more likely to cause gastrointestinal upset than meloxicam, but meloxicam may interact with blood pressure medications more than ibuprofen12.Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.
Ibuprofen blocks COX-1, the enzyme that protects your stomach from irritation. This means that ibuprofen is more likely to upset your stomach than meloxicam. Meloxicam mostly blocks COX-2 rather than COX-1, particularly at lower doses. “Ibuprofen is more likely to cause gastrointestinal upset compared to meloxicam,” says Dr. Pala.
www.healthcentral.com/drug/drug-interactions/can …Meloxicam is easier on the stomach than Ibuprofen. That is the biggest difference, since they are both nonsteroidals' they work the same. However be careful and always always consult you Dr. because Meloxicam is a little harder on you than ibuprofen if you are on BP meds.www.drugs.com/answers/difference-between-melo… - People also ask
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