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  1. Meloxicam, a COX-2 Preferential Nonsteroidal Anti …

    WebPharmacokinetics. Meloxicam is well absorbed after oral administration, with an absolute bioavailability of 89% that is not markedly affected by concomitant intake of food. Meloxicam...

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    The absolute bioavailability of meloxicam capsules was 89% following a single oral dose of 30 mg compared with 30 mg IV bolus injection. Following single intravenous doses, dose-proportional pharmacokinetics were shown in the range of 5 mg to 60 mg.
    After multiple oral doses the pharmacokinetics of meloxicam capsules were dose-proportional over the range of 7.5 mg to 15 mg. Mean Cmaxwas achieved within four to five hours after a 7.5 mg meloxicam tablet was taken under fasted conditions, indicating a prolonged drug absorption.
    Each pastel yellow tablet contains 7.5 mg or 15 mg meloxicam for oral administration. Each bottle of oral suspension contains 7.5 mg meloxicam per 5 mL. Meloxicam is chemically designated as 4- hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1- dioxide. The molecular weight is 351.4.
    A second meloxicam concentration peak occurs around 12 to 14 hours post-dose suggesting biliary recycling. Meloxicam oral suspension doses of 7.5 mg/5 mL and 15 mg/10 mL have been found to be bioequivalent to meloxicam 7.5 mg and 15 mg capsules, respectively. Meloxicam capsules have been shown to be bioequivalent to Mobic® (meloxicam) tablets.
  3. Meloxicam (Watson Laboratories Inc.): FDA Package Insert

  4. DailyMed - MELOXICAM tablet

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  6. Evaluating bioequivalence of meloxicam tablets: is

  7. Bioequivalence study of a novel orodispersible tablet of …

  8. Pharmacokinetic and bioequivalence study of meloxicam tablets in ...

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